Facebook ← Previous Next → Sponsored By: Postmedia Network Inc. President and CEO Andrew MacLeodPeter J Thompson/National Post Recommended For YouYields fall on weak housing, U.S.-China trade concernsIMF sees dangers from trade tensions, overvalued dollarGerman finmin: Libra cryptocurrency must wait for regulatory clarityCanadian inflation dips to 2.0% in June, hitting central bank targetJapan to reject South Korea’s request for meeting on export curbs – Kyodo Comment Postmedia posts net loss of $5.1 million as digital revenue growth streak continues Digital revenues up 10.2% in ninth consecutive quarter of double-digit growth Email Victor Ferreira That’s been hard to do while competing with juggernauts such as Facebook Inc. and Alphabet Inc.’s Google for digital revenue. “You’re going up against these two players on a global scale that literally own 70-80 per cent of the market,” he said. “Every day before you wake up, most budgets have already been pre-allocated to these two platforms.”The federal government’s plan to invest $595 million in local journalism should assist Postmedia in continuing to make its transition from relying on print revenue streams to those in the digital realm. Postmedia and other Canadian media companies will be eligible for tax credits that are tied to the salaries of the journalists they employ. Because the credit is tied to jobs, MacLeod said it may force companies to think long and hard about future layoffs.He also sees the new cash as a revenue stream that will help the company “play offence” and steer it towards growth — something he said Postmedia can focus on even as it pays off millions of dollars in debt. The company paid off another $20.4 million in debt, as well an additional $5.5 million subsequent to the quarter’s end, bringing the total it owes in first-lien notes down to $99.7 million.While releasing its results on Thursday, Postmedia also announced that MacLeod has been appointed to the boards of directors of both the company and its subsidiary. The company also appointed Mary Anne Lavallee to the role of executive vice-president and chief operating officer. Lavallee joined Postmedia in 2014 and had been working as its senior vice-president of reader sales and commercial operations.• Email: email@example.com | Twitter: Share this storyPostmedia posts net loss of $5.1 million as digital revenue growth streak continues Tumblr Pinterest Google+ LinkedIn More Postmedia Network Canada Corp. posted its ninth consecutive quarter of double-digit digital revenue growth on Thursday, but declining print revenues and an impairment charge contributed to a net loss of $5.1 million for the company’s fiscal second quarter.In the three months ending Feb. 28, 2019, Postmedia, which is Canada’s largest newspaper chain, saw its revenue decline to $145.7 million from $157.6 million in the same period last year.The drop in the Postmedia second fiscal quarter, the company said, was due to a $10 million decrease in print advertising and a $2.9 million decline in print circulation revenue. The company noted, however, that the rates of decline for both metrics slowed as compared to last year.Overall, the company’s net loss increased from the same period in 2018, when it posted a $1.3 million loss. Postmedia attributed the difference to an impairment charge and a tax credit recovery in the second quarter of 2018 being offset by gains it made through selling property and equipment.Digital revenues, however continued to grow and were up 10.2 per cent to $28.18 million in comparison to $26.37 million in the same period last year.“We’ve clipped our debt by $125 million, we’ve got nine quarters of (digital) growth and we’ve seen improvements in the rates of decline,” said Andrew MacLeod, Postmedia’s president and chief executive. Despite the progress, MacLeod said he had no illusions about the challenges facing the company and the industry.“No one is sitting here on the executive floor and cracking open champagne and feeling great about life,” MacLeod said. ”There’s a heck of a lot of work in front of us and we know that.”MacLeod, who took over as Postmedia CEO from Paul Godfrey in January, said that the main challenge is to grow digital revenue, not just incrementally, but to the point where it surpasses what the company is earning in both print advertising and print circulation — a combined $110.7 million in the second quarter. This has to be accomplished, MacLeod said, while slowing the erosion of legacy revenues.We’ve clipped our debt by $125 million Featured Stories Reddit 7 Comments Twitter April 11, 20196:53 PM EDT Filed under News Join the conversation → What you need to know about passing the family cottage to the next generation advertisement
CharIN: CCS Combo Standard To Offer V2G By 2025 Nuvve Announces Vehicle-to-Grid (V2G) Pilot Programs Engie seeks how to make V2G cheap and profitableIn one of the latest episodes of Fully Charged, Robert Llewellyn checked out the Vehicle-To-Grid (v2G) system installed by Engie at its head office outside Amsterdam in the Netherlands.French electric utility company seeks how to implement bi-directional charging with energy storage and solar installations at the lowest possible costs. Ability to use electricity from cars could be profitable for peak shaving (of electricity demand) or handy in case of emergency, but we are not there yet.V2G news Source: Electric Vehicle News In case of demo installation, Engie uses CHAdeMO chargers and Mitsubishi Outlander PHEV (other CHAdeMO-compatible cars also can be connected). As of today, CCS is not yet ready for bi-directional charging, which probably will be a major obstacle in commercialization. Honda Launches Wireless V2G With WiTricity Author Liberty Access TechnologiesPosted on February 2, 2019Categories Electric Vehicle News
Electric Peugeot 208 coming soon.French media obtained leaked images of the upcoming all-electric Peugeot e208, which is expected to be unveiled at the 2019 Geneva Motor Show.The Peugeot e208 reportedly will share powertrain and batteries with DS 3 Crossback E-Tense (scheduled for arrival in the second half of 2019). The 50 kWh battery should be enough for up to 300 km (186 miles) of range under the WLTP test cycle.PSA news As we’ve hinted at recently, the 2019 Geneva Motor Show will certainly be the single largest electric car debut venue the world has ever seen. We sure are excited for this shift change from gas/diesel debuts to vehicles with plugs. As the public venture out to the show in Geneva, it will be immediately obvious that the focus in on electric. Stay tuned as there’s so much more electrifying info to come in the lead up to the show.Please feel free to leave a comment on the looks of the e208 and interior of the new electric car.Here are the images:Peugeot e208 (Source: automobile-propre.com) Opel/Vauxhall Teases All-New Corsa: EV Version Coming Nuevo PEUGEOT 2 0 8 . #peugeot208 #new208 #208 #clubpeugeotrd #peugeotrepublicadominicana #newsA post shared by Club Peugeot RD (@clubpeugeotrd) on Feb 21, 2019 at 6:39pm PST 508 Peugeot Sport Engineered PHEV Concept Revealed Source: automobile-propre.com, leblogauto.com, auto-motor-und-sport.de Source: Electric Vehicle News View this post on Instagram Peugeot e208 (Source: automobile-propre.com) DS 3 Crossback Electric CUV Comes Packing 50-kWh Battery Author Liberty Access TechnologiesPosted on February 23, 2019Categories Electric Vehicle News
Watch Tesla Model 3 Race Corvette Z06 & Dodge Challenger: Video Top speed secured.The Tesla Model 3, especially the Performance variant, is highly capable of running at high speeds. It’s more known for its off-the-line acceleration, but it’s a capable flat-out car too.More Model 3 News Go Green In A Tesla Model 3 For St. Patrick’s Day Author Liberty Access TechnologiesPosted on March 17, 2019Categories Electric Vehicle News Now that the Model 3 is becoming increasingly common in Europe, we get chances to see how it performs on the unlimited speed sections of the Autobahn and that’s precisely what’s captured here.Watch this impressive acceleration run in a Tesla Model 3 Performance. It hits 153 MPH on the Autobahn and remains super steady. That’s very impressive for a midsize family sedan that’s not really built for ultimate speed.Video description:TESLA MODEL 3 PERFORMANCE 0-247km/h ACCELERATION & TOP SPEED by AutoTopNLAuto-Top is an honest and pure car filming and testing company. We’re not interested in eco & green (unless it’s like, really superfast). Screaming exhausts, whining superchargers and blowing turbo’s is what we want to hear!We review all sorts of performance cars. In the different playlists you can enjoy exhaust sounds, acceleration tests (0-100, 0-200) with launch control, onboard cams and the revving sound of each car.Exotic cars, hot hatches, power sedans. We have it all! Source: Electric Vehicle News New Tesla Electric Pickup Render Is Bold, Reminds Us Of Ram Truck
Tesla has issued an OTA update and NIO has recalled just under 5,000 vehicles.Source: Electric Vehicle News
Tue 22 Jan 2008 21.26 EST Share on Messenger Share on Twitter Liverpool Share on WhatsApp news Soccer Share on LinkedIn Share on Twitter Share via Email Shares00 Reuse this content First published on Tue 22 Jan 2008 21.26 EST David Conn This article is more than 11 years old Soccer Share via Email Tom Hicks and George Gillett’s hold on Liverpool appeared to be strengthening last night despite supporters’ protests and rumours that the American owners’ refinancing deal had stalled. Sources close to the negotiations for a £350m loan Hicks and Gillett are seeking from the Royal Bank of Scotland and the US Bank Wachovia insisted yesterday that the deal is due to be signed this week, with Hicks hoping to announce its completion tomorrow.Stories circulated yesterday that following Monday’s stock market crash RBS had asked Hicks and Gillett to increase the amount in guarantees they are personally giving to support the new borrowing, and that the new demands were causing them problems.However, sources at both Liverpool and in the City maintained that those details have already been agreed, and that arrangements are holding firm despite the turmoil of the last fortnight. Hicks and Gillett are indeed understood to have increased their guarantees in recent weeks from £30m each to around £55m.The pair borrowed the £185m to buy Liverpool last February and were lent a further £113m by the Royal Bank of Scotland for 12 months, to absorb the club’s debts, sign players and finance initial work on the club’s new stadium. They are seeking to refinance that total loan of £298m, and with interest and further work required on the stadium the new loan is understood to amount to around £350m.The two co-owners are understood to have agreed to contribute £40m in cash between them, as well as the personal guarantees and letters of credit.At Anfield, fans have turned against Hicks and Gillett following Hicks’s admission that they talked to Jürgen Klinsmann about the manager’s job should their relationship with Rafael Benítez collapse.Dubai International Capital, the private equity group largely investing the fortune of Sheikh Mohammed bin Rashid al-Maktoum, the hereditary ruler of Dubai, then re-emerged as a potential buyer for the club, but have been adamant they will not hand a huge profit to Hicks and Gillett.There has been speculation that the pair have fallen out and Gillett might combine with DIC to buy out Hicks, but Hicks himself has insisted all along that he sees Liverpool as a long-term investment, and that he has no intention of selling now. This article is more than 11 years old Share on Facebook Share on Facebook Share on Pinterest Owners set to strengthen grip on Liverpool as deal stays alive Topics George Gillett and Tom Hicks remain at loggerheads over the future of Liverpool. Photograph: Jason Cairnduff/Action Images
Eight days remain in December, but already it’s been a December to remember from a Foreign Corrupt Practices Act enforcement perspective.Thus far this month, there have been four corporate enforcement actions resulting in $923 million in settlement amounts.The stocking stuffer of course was yesterday’s announcement by the DOJ of a $772 million FCPA enforcement action against Alstom and related entities.While the Alstom enforcement action is the largest DOJ FCPA enforcement action of all-time, it is the second largest overall FCPA enforcement action of all-time behind the 2008 Siemens enforcement action ($450 million DOJ component and a $350 million SEC component). To see the current FCPA top-ten settlement list, click here.The Alstom resolution documents total approximately 400 pages. A future post will comprehensively summarize these documents.In short, and as highlighted in the DOJ’s release:“Alstom pleaded guilty to a two-count criminal information filed today in the U.S. District Court for the District of Connecticut, charging the company with violating the Foreign Corrupt Practices Act (FCPA) by falsifying its books and records and failing to implement adequate internal controls. Alstom admitted its criminal conduct and agreed to pay a criminal penalty of $772,290,000. U.S. District Judge Janet B. Arterton of the District of Connecticut scheduled a sentencing hearing for June 23, 2015.In addition, Alstom Network Schweiz AG, formerly Alstom Prom (Alstom Prom), Alstom’s Swiss subsidiary, pleaded guilty to a criminal information charging the company with conspiracy to violate the anti-bribery provisions of the FCPA. Alstom Power Inc. (Alstom Power) and Alstom Grid Inc. (Alstom Grid), two U.S. subsidiaries, both entered into deferred prosecution agreements, admitting that they conspired to violate the anti-bribery provisions of the FCPA. Alstom Power is headquartered in Windsor, Connecticut, and Alstom Grid, formerly Alstom T&D, was headquartered in New Jersey.According to the companies’ admissions, Alstom, Alstom Prom, Alstom Power and Alstom Grid, through various executives and employees, paid bribes to government officials and falsified books and records in connection with power, grid and transportation projects for state-owned entities around the world, including in Indonesia, Egypt, Saudi Arabia, the Bahamas and Taiwan. In Indonesia, for example, Alstom, Alstom Prom, and Alstom Power paid bribes to government officials – including a high-ranking member of the Indonesian Parliament and high-ranking members of Perusahaan Listrik Negara, the state-owned electricity company in Indonesia – in exchange for assistance in securing several contracts to provide power-related services valued at approximately $375 million. In total, Alstom paid more than $75 million to secure $4 billion in projects around the world, with a profit to the company of approximately $300 million.Alstom and its subsidiaries also attempted to conceal the bribery scheme by retaining consultants purportedly to provide consulting services on behalf of the companies, but who actually served as conduits for corrupt payments to the government officials. […]The plea agreement cites many factors considered by the department in reaching the appropriate resolution, including: Alstom’s failure to voluntarily disclose the misconduct even though it was aware of related misconduct at a U.S. subsidiary that previously resolved corruption charges with the department in connection with a power project in Italy; Alstom’s refusal to fully cooperate with the department’s investigation for several years; the breadth of the companies’ misconduct, which spanned many years, occurred in countries around the globe and in several business lines, and involved sophisticated schemes to bribe high-level government officials; Alstom’s lack of an effective compliance and ethics program at the time of the conduct; and Alstom’s prior criminal misconduct, including conduct that led to resolutions with various other governments and the World Bank.After the department publicly charged several Alstom executives, however, Alstom began providing thorough cooperation, including assisting the department’s prosecution of other companies and individuals.”Stay tuned for a future post that will comprehensively summarize the various prongs of the Alstom enforcement action.
Not a subscriber? Sign up for The Texas Lawbook. Lost your password? Remember me © 2014 The Texas Lawbook.By Brooks IgoStaff Writer for The Texas Lawbook(February 26) — Domestic and international franchise experts Will Woods and Ann Hurwitz recently joined Baker & McKenzie’s Dallas office from Baker Botts. The duo has represented companies in the hospitality, restaurant and retail industries.Woods, who focuses his practice on franchise M&A, said Baker & McKenzie’s 75 offices worldwide were a big factor in his decision to lateral over.“Baker & McKenzie has a market leading network,” he said. “It is a terrific . . .You must be a subscriber to The Texas Lawbook to access this content. Password Username
Jun 14 2018A new study authored by scientists from the American Cancer Society, the Harvard T.H. Chan School of Public Health, the U.S. National Cancer Institute, and more than 20 other medical centers and organizations finds that higher circulating vitamin D concentrations are significantly associated with lower colorectal cancer risk. This study strengthens the evidence, previously considered inconclusive, for a protective relationship. Optimal vitamin D concentrations for colorectal cancer prevention may be higher than the current National Academy of Medicine recommendations, which are based only on bone health. The study appears online in the Journal of the National Cancer Institute.Vitamin D, known for its role in maintaining bone health, is hypothesized to lower colorectal cancer risk via several pathways related to cell growth and regulation. Previous prospective studies have reported inconsistent results for whether higher concentrations of circulating 25-hydroxyvitamin D, the accepted measure of vitamin D status, are linked to lower risk of colorectal cancer. The few randomized clinical trials of vitamin D supplementation and colorectal cancer completed thus far have not shown an effect; but study size, supplementation duration, and compliance may have contributed to their null findings.”To address inconsistencies in prior studies on vitamin D and to investigate associations in population subgroups, we analyzed participant-level data, collected before colorectal cancer diagnosis, from 17 prospective cohorts and used standardized criteria across the studies,” said Stephanie Smith-Warner, PhD, an epidemiologist at the Harvard T.H. Chan School of Public Health and co-senior author on the article. The analysis included over 5,700 colorectal cancer cases and 7,100 controls from the United States, Europe, and Asia. A single, widely accepted assay and laboratory was used for new vitamin D measurements and calibration of existing vitamin D measurements. “In the past, substantial differences between assays made it difficult to integrate vitamin D data from different studies,” explained Regina G. Ziegler, PhD, a National Cancer Institute epidemiologist and co-senior author on the article. “This calibration approach enabled us to systematically explore risk over the broad range of vitamin D levels seen internationally.”Related StoriesNew research links “broken heart syndrome” to cancerResearchers use AI to develop early gastric cancer endoscopic diagnosis systemResearchers identify potential drug target for multiple cancer typesCompared to participants with circulating vitamin D concentrations considered sufficient for bone health, those with deficient concentrations of vitamin D had a 31% higher risk of colorectal cancer during follow-up, which averaged 5.5 years (range: 1 – 25 years). Similarly, concentrations above bone health sufficiency were associated with a 22% lower risk. However, risk did not continue to decline at the highest concentrations. These associations persisted even after adjusting for known colorectal cancer risk factors. Protective associations were seen in all subgroups examined. However, the association was noticeably stronger in women than men at concentrations above bone health sufficiency. The lifetime risk of colorectal cancer is 4.2% (1 in 24) in women and 4.5% (1 in 22) in men. Colorectal cancer is the third most common cancer and third leading cause of cancer-related deaths in both men and women in the United States, with about 140,250 new cases and 50,630 deaths expected during 2018.”Currently, health agencies do not recommend vitamin D for the prevention of colorectal cancer,” said Marji L. McCullough, ScD, American Cancer Society epidemiologist and co-first author of the study. “This study adds new information that agencies can use when reviewing evidence for vitamin D guidance and suggests that the concentrations recommended for bone health may be lower than would be optimal for colorectal cancer prevention.”Vitamin D can be obtained in the diet, particularly from fortified foods, from supplements, and from sun exposure. Experts recommend vitamin D be obtained through diet whenever possible because excessive ultraviolet radiation is a major risk factor for skin cancer. Source:https://www.cancer.org/
Source:https://www.niaid.nih.gov/news-events/pregnancy-loss-occurs-26-percent-zika-infected-monkeys Jul 3 2018Fetal death in utero occurred in more than one-fourth of monkeys infected in the laboratory with Zika virus in early pregnancy, according to new research published in Nature Medicine. The finding raises the concern that Zika virus-associated pregnancy loss in humans may be more common than currently thought, according to the study authors.A large team of experts aggregated data on Zika-infected macaques from six National Primate Research Centers (NPRCs) in the United States for the new analysis. The study was funded in part by the National Institute of Allergy and Infectious Diseases (NIAID) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), both components of the National Institutes of Health.Related StoriesStudy uncovers potential new way to prevent common pregnancy-related complicationsPre-pregnancy maternal obesity may affect growth of breastfeeding infantsCannabis use during pregnancy may cause premature birthZika virus is most often transmitted to humans via the bite of an infected Aedes aegypti mosquito. It also is transmitted sexually. Many people infected with Zika virus will not have symptoms; others may have fever, rash, headache, joint pain, red eyes, and muscle pain. Zika virus can be passed from an infected pregnant woman to her fetus and cause a range of birth defects collectively known as congenital Zika syndrome. Although Zika virus was first discovered in 1947, Zika-related birth defects were not reported until 2015 during a large outbreak of Zika in the Americas. No licensed treatments or vaccines for Zika virus are currently available, but many are in various stages of development. For example, NIAID is leading an international Phase 2 trial of an experimental Zika vaccine.Research recently published in the New England Journal of Medicine showed a 5.8 percent miscarriage rate and a 1.8 percent stillbirth rate in a cohort of pregnant women with symptomatic Zika virus infection in French Guiana, Guadalupe or Martinique. Authors of the new nonhuman primate analysis note that the rates from the NEJM study could be an underestimate–the study included only symptomatic pregnant women, whereas many people with Zika infection are asymptomatic.For the new analysis, experts combined published and unpublished data from various studies of pregnant macaques infected with Zika virus. Fetal death (miscarriage or stillbirth) occurred in 13 of 50 (26 percent) of the animals studied. Macaques infected early in pregnancy had significantly higher rates of fetal death than those infected after gestation day 55. The results track with human data showing more severe fetal outcomes in women infected with Zika in their first trimester compared to those infected later in pregnancy. The rates of fetal death in macaques underscore the need for careful monitoring of fetal loss and stillbirth in Zika-affected human pregnancies, the authors write.
Reviewed by James Ives, M.Psych. (Editor)Aug 27 2018Researchers at UBC’s Okanagan campus have developed a new and improved method to judge the effectiveness of experimental therapies for neurodegeneration–the progressive loss of neurons.”Neurons–or nerve cells–are hugely important to our daily lives,” says post doctoral fellow Aaron Johnstone and study lead author. “These specialized cells collect and process the large amounts of information that enter our bodies via our senses, control our muscles and organs, and form our thoughts and memories. When these cells become unhealthy, it leads to diseases like Alzheimer’s and Parkinson’s, ALS, glaucoma and chronic pain.”Related StoriesNew shingles vaccine reduces outbreaks of painful rash among stem cell transplant patientsNew study reveals ‘clutch’ proteins responsible for putting T cell activation ‘into gear’Slug serves as ‘command central’ for determining breast stem cell healthJohnstone says his study uses the first automated test specifically designed for measuring degeneration of sensory neurons grown in a lab.”The variability in nerve cell lengths, densities and shapes have traditionally made it difficult to reliably analyze their health,” says Johnstone. “This, in turn, has generated confusion about the effectiveness of potential pharmacological or genetic treatments.”Using the new approach, which is software-assisted, the research team were able to measure nerve cell densities more accurately.To do this the team grew nerve cells in a lab environment, and after establishing healthy neurons researchers mimicked the conditions that cause neurodegeneration. Neuron loss was then captured using fluorescent microcopy–a process that makes the tiny cells easier to see–and analyzed using a computer algorithm.Johnstone suggests that objective measurement is essential to the process of developing new medicines.”This procedure makes evaluating new treatment options, like drugs or gene therapies, far more accurate and trustworthy,” Johnstone adds. Source:https://ok.ubc.ca/
Reviewed by Alina Shrourou, B.Sc. (Editor)Sep 4 2018Imagine if most children with cancer were treated by a doctor with no training or experience in cancer. It doesn’t seem possible. In epilepsy, however, it’s more common than not. That’s because pediatric neurologists are few and far between in almost every country; in some countries there are no specialists at all, or only a handful to serve millions of children. In addition, local medical personnel-; pediatricians, family doctors, physician assistants and nurses-;often have little training in, knowledge of or experience with epilepsy.This phenomenon was known, and accepted, for many decades. Until a perfect storm of events in the United Kingdom began to change everything.A turning point for epilepsy careAt the turn of this century, a report quietly released in London made clear that in the UK, most children with epilepsy were treated by pediatricians with no specialized training in epilepsy. This report followed on the heels of at least five similar reports.At about the same time, a pediatrician in England came under investigation for misdiagnosing and overtreating children with epilepsy. Amid lawsuits and headlines, it was clear that this doctor had no malicious intent-;and that his high rate of misdiagnosis was far from unusual among general physicians. At the time, only 62 pediatric neurologists served the entire United Kingdom, so most children with epilepsy would never see one.Then a UK survey -; The National Sentinel Clinical Audit of Epilepsy-Related Death -; found that 77% of children who died with epilepsy had deficiencies in their care, and 59% of the deaths were avoidable. The numbers of children studied were small, but the conclusions were powerful.Both the National Institute for Health and Care Excellence (NICE) and the Scottish Intercollegiate Guidelines Network had published guidelines on the diagnosis and management of epilepsy in children. Yet the reports, surveys and investigations highlighted a tremendous gap between those guidelines and everyday practice.Pediatric neurologists and the British Paediatric Neurology Association (BPNA) realized that something had to be done to raise the standard of care, said Philippa Rodie, BPNA executive director. “The BPNA decided to train pediatricians to better diagnose epilepsy and treat it, and how to recognize when to refer children to specialists,” she said.The result was Pediatric Epilepsy Training (PET).Providing training, reducing stigmaThe BPNA established three courses: PET1, and PET2 & 3. The higher-level courses are specialized and are intended for pediatricians, nurses and trainees who wish to develop a specialty in epilepsy.The association’s PET1 course casts the widest net. It’s aimed at all health professionals -; anyone who may see or treat a child who could have epilepsy, said Rodie. “I’ve stopped talking about people’s job titles [as a requirement] for this course,” she said. “It’s not about the job title; it’s about people who see children.”PET1 teaches how to differentiate between what is epilepsy and what isn’t, as well as how to distinguish among the different types of epilepsy. It covers treatment, referral skills, comprehensive care planning and a focus on the holistic care of the child-;and the family.”There’s a huge amount of stigma attached to epilepsy around the world,” said Rodie. “Kids end up being excluded from activities, and in some parts of the world they’re excluded from school altogether. The course encourages offering the family information to give to the teacher about what to do if the child has a seizure, or to the football coach or ballet instructor-;so the child can lead a normal life.”Courses are run by trained, volunteer faculty members -; usually pediatric neurologists, pediatricians and epilepsy nurses -; and are limited to 48 attendees. Each day-long course consists of lectures and smaller workshops that allow for interaction and multiple forms of learning.In 2005, the BPNA ran the first PET1 course in the UK. By 2014, more than 4,500 people had attended.Making a differenceAlso between 2005 and 2014, the UK experienced dramatic improvements in pediatric epilepsy care, including annual decreases in incidence (presumably reflecting fewer misdiagnoses), improved adherence to nationally published clinical guidelines, and the establishment and expansion of epilepsy care teams, clinics and networks. PET1 courses have been cited as one of several pivotal factors underlying this sea change, and the Joint Epilepsy Council bestowed an award on BPNA for its efforts. The Royal College of Pediatrics and Child Health now requires PET attendance for any pediatrician who wishes to register with the National Health Service as having a special interest in epilepsy.Besides their official endorsement, PET1 courses have real-world clout among health care providers. Though the courses are not mandatory, PET1 attendance is often a requirement on job descriptions for pediatricians who will be seeing children with epilepsy. And pediatricians themselves expect that colleagues who see children with seizures will have attended the course.After a few years of running courses, it was clear that pediatricians in the UK were spreading the word to their colleagues around the world. The BPNA began receiving inquiries from other countries grappling with the same issues. In 2012, the BPNA began offering PET1 in Qatar. In 2013, it started courses in United Arab Emirates. In 2014, courses were established in India.By the end of this year, 13 countries across 5 continents will be offering PET1: Brazil, India, Ireland, Ghana, Kenya, Myanmar, New Zealand, South Africa, Sudan, Tanzania, Uganda, United Arab Emirates and the UK. More countries are in the works, Rodie said, though “We have a longer list of countries that want these courses than we have resources.”How it works: Delivering PET around the worldHow do countries begin delivering PET courses? It begins with an inquiry to the BPNA from a local pediatric association or ILAE chapter. That’s followed by discussion, a proposal and a signed agreement about running the courses (“memorandum of understanding”).”The memorandum spells out what BPNA will do and what the association or chapter will do, so everyone’s clear about expectations,” Rodie said. “We have clear aims in line with local and national targets around the management of epilepsy.” The local contact recruits faculty, who must be affiliated with a local pediatric neurology association or ILAE chapter. “We look for people who are part of epilepsy networks, who are well trained, and who have credibility in the community,” Rodie said.BPNA then travels to the country, trains the faculty and launches the first PET1 course, all in one go. On the first day, BPNA trainers deliver the course to the new faculty members. The second day is training day, on which new faculty learn how to teach the course. On the third day, with the BPNA trainers as mentors, the newly trained faculty deliver their first PET1 course to paying attendees.To bring dozens of busy pediatricians together in one place for multiple days isn’t easy or inexpensive, so efficiency is key. “In India we had faculty leads in four cities, and they each recruited six to eight faculty members and brought them all to one site,” Rodie said. “We trained them all, so by the end of the three days, we had groups that could run courses in those four cities.”Earlier this year, BPNA followed the same model in Kenya. “We had leads from Kenya, Ghana, Uganda and Tanzania -; they’d each recruited faculty,” she said. “They all came to Kenya, we delivered the training there and they went back to their countries.” Ghana and Uganda have delivered two courses each to local attendees. Tanzania and Kenya have courses scheduled later in 2018.Each group must offer a minimum of one course a year for five years. “Sudan, Ghana and Tanzania are running two courses, two days in a row,” Rodie noted. “That’s a very efficient way of running it financially, because the faculty have to travel only once, but they can deliver the course to 96 people.”Related StoriesCancer killing capability of lesser-known immune cells identifiedResearchers identify gene mutations linked to leukemia in children with Down’s syndromeMany thyroid cancer patients have no choice about radioactive iodine, study revealsInternational cooperationShortly after its development, PET1 was updated every other year; now, it’s updated every three years. At the most recent review meeting, BPNA welcomed 21 reviewers from 12 countries.”What we thought would happen [at the review] was that we’d get people from all these countries and they’d say, ‘We need to develop the course for my country like this’, but they found consensus – anything they needed to alter for their country, they discovered that other people had the same issue,” said Rodie. “We ended up with a generic course, with just a few specific changes for for certain countries.”The ILAE formally endorsed PET in December 2017 and will be working with the BPNA to ensure its global research increases. The collaboration allows the ILAE and its national chapters to encourage and support basic epilepsy education to front-line health care providers through the expertise of the BPNA in areas of the world where there is a great need.PET1 has been translated into Portuguese and Spanish for use in Central and South America. Brazil is the first country to use the translated course; it will launch its first PET1 course in September 2018.Changing practice -; for the betterThe course is well-received by attendees. In post-course surveys, 99% rate the course as excellent or very good, and 95% said they would definitely recommend the course to colleagues.Each attendee takes a quiz before and after the course, so BPNA can assess baseline knowledge and the course’s effect. Six months after each course, BPNA emails a survey to the attendees to measure their changes in attitudes and practice. “We want to see if what they’ve learned has made a difference on the ground,” said Rodie.Here’s a sampling of results from 2017 surveys: PET in AfricaThe need for pediatric epilepsy knowledge in Africa is acute; most countries have no pediatric neurologists, and the rest have only a few. For example, Ghana, with a population of 28 million people, has two accredited pediatric neurologists. At the same time, epilepsy is one of the major disease burdens across the continent.In February 2016, 35 doctors from 10 African countries met in Cape Town for PET1 training. Jo Wilmshurst, head of pediatric neurology at Red Cross War Memorial Children’s Hospital, University of Cape Town, coordinated the training after seeing Sudan establish PET1. The idea was to rotate PET1 courses across key regions in South Africa.Two years later, demand for PET1 in Africa had skyrocketed. A second training course took place in April 2018 in Kenya, resulting in enough trained faculty members to offer courses in Ghana, Uganda, Tanzania and Kenya. In 2019, they hope to offer courses in Ethiopia. By the end of 2018, Wilmshurst says, more than 400 attendees will have taken PET1 in Africa.”The practical and concise nature of the course has a huge impact on providing pathways to empower health care practitioners to deliver better care,” Wilmshurst said. “Following the recommendations in the PET course enables standardization of the approach to many common situations in the care of children with seizures. This training has been lacking in Africa, and the enthusiasm of the clinicians illustrates the need for this intervention.”GhanaPET’s impact is powerful, agreed Charles Hammond, a PET faculty member and pediatric neurologist at Komfo Anokye Teaching Hospital in Kumasi, Ghana. As with most other countries, Ghana’s specialists practice in the major cities. Most children with epilepsy live hundreds of miles away, so they get care from pediatricians, general physicians and physician assistants.Hammond viewed becoming a PET1 faculty member as an “excellent opportunity to improve my knowledge and skill in managing epilepsy in children . . . and bring knowledge to pediatricians and other doctors in Ghana who manage children with epilepsy.”KenyaIn Kenya, the courses have already begun to change the way that pediatricians manage epilepsy care, said Pauline Samia, PET faculty member and interim chair of the Department of Pediatrics at Aga Khan University Hospital, Nairobi. “We hope to be able to impact medical officers in this region as well, given that only a small proportion of children have access to a pediatrician for their care,” she said. One clear impact of PET1 is that Kenyan physicians are now petitioning county governments and hospitals to provide a consistent supply of anti-epilepsy drugs.SudanAhlam Hamed attended PET1 training in India and has helped to oversee four courses in Sudan, where she is a pediatric neurologist at Soba University Hospital and associate professor at the University of Khartoum. “These courses enable us to distribute basic pediatric epilepsy knowledge-;mainly, the wide range of non-epilepsy diagnosis possibilities and the limited diagnostic value of EEG,” she said. Hamed hopes that the increased knowledge of how to manage status epilepticus will engender support to bring buccal midazolam to Sudan (it is currently not available), as well as to reductions in morbidity and mortality.UgandaAngelina Kakooza-Mwesige has been involved with PET1 since 2016. Kakooza is a pediatric neurologist and lecturer at the School of Medicine, Makerere University College of Health Sciences, Kampala. She envisions a future in which the course has helped epilepsy knowledge increase in Uganda to a tipping point, after which “it will greatly improve the practice and standard of care for children with epilepsy in the region,” she said. “Children will obtain standard diagnoses and proper treatment, a full work-up of each child will be done and there will be cross-country consultations on difficult cases.” 85% report improved diagnosis skills 82% report improved history taking 80% are trying to improve the way that clinical services are set up to support children with epilepsy 63% say they more quickly recognise when a patient needs to be referred to an expert 58% report they always provide first aid advice to parents and caregivers 57% have introduced changes that have improved information sharing in their unit 54% have introduced changes that have improved the management of prolonged seizures Source:https://www.ilae.org/
Mining the exotic metals used in modern electronics inflicts a lot of damage on the environment, especially by polluting the atmosphere with carbon dioxide. But overall, the global warming impact of metals is still dominated by the old-school elements iron and aluminum. That’s one of the bottom lines from a comprehensive environmental analysis of 63 metals, published this week in PLOS ONE. Iron (Fe), and its alloy steel, are the dirtiest of the bunch, responsible for 30% of all industrial CO2 emissions. The runner up is aluminum (Al) at 2% of CO2. In third place—perhaps a surprise to some readers—is calcium (Ca), an alkaline earth metal. It’s mined for quicklime, an ingredient in cement. (What typically consumes the most energy is not getting the rock out of the ground, but refining the ore. All told, producing metals takes 9.5% of world energy.) Other environmental damage related to production, such as acid-mine drainage, is also dominated by these common metals. A unique aspect of the study is that it teases apart the environmental impact of each element, even though many are mined or processed in combinations. The detailed analysis could help engineers design products that substitute more benign metals.
If you find people watching oddly compelling, you’re not alone. A new study suggests that gregarious European starlings (Sturnus vulgaris) get a kick out of looking at their fellow birds, even if it’s just on a computer screen. Researchers took 10 captive starlings from their flock and isolated them for 4 days in a cage with plenty of food and water and a large flat-screen monitor. Most of the birds quickly discovered that poking their beaks into one sensor in the cage flashed a life-size photograph of an unknown starling onto the screen, while a second sensor produced a picture of a suburban landscape. The lonely birds seemed to enjoy looking at other starlings, the researchers found. On average, they triggered a new starling photo every 6 minutes, 7 hours a day, for 4 days. They only threw in a landscape every 20 minutes or so. It wasn’t just that the landscapes were boring. Given the choice between photos of starlings and photos of monkeys, a second group of five birds also pecked to view their own kind three times more often. The results suggest starlings have a natural yearning for social stimulation, the authors report online this month in Animal Cognition. In the future, starlings’ drive to view photos of one another could be used to study the social rewards that knit communities together.